Polynucleotides are purified nucleotide injections, often derived from fish DNA, used to support skin hydration, elasticity and texture. At Transform Beauty in Horsham they are commonly used for crepey under-eyes, neck and hands, usually as two to three sessions three to four weeks apart. Results vary.
Support natural skin renewal. Improve hydration. Refresh the appearance of your skin.
Polynucleotide treatments are injectable skin-quality procedures designed to support the appearance and condition of the skin.
Depending on the approved formulation used, polynucleotides may help improve:
They do not normally create the same lifting, contouring or volumising effect associated with traditional dermal fillers.
At Transform Beauty, every treatment is personalised according to your skin, medical suitability, concerns and desired outcome.
Polynucleotides are chains made from nucleotide units, which are biological building blocks found within DNA and RNA.
In aesthetic treatments, highly purified polynucleotide-based injectable formulations are used as skin-quality products.
Depending on the specific product, they may be intended to support:
Hydration
Skin elasticity
Smoother-looking texture
Skin resilience
Overall skin quality
The appearance of fine lines
The exact source and composition depend on the product used.
The website should only state that a formulation is derived from fish, salmon, trout or another biological source when this has been confirmed through the official product documentation.
Published aesthetic research has reported possible improvements in skin texture, elasticity, hydration and wrinkle appearance, but findings vary and larger, higher-quality studies are still needed.
Polynucleotide formulations are placed into selected layers of the skin using a series of small injections.
They are intended to create a supportive environment for skin-quality processes rather than to provide significant structural volume.
The proposed effects described in aesthetic literature include support for:
These effects are not guaranteed and vary from person to person.
Research on polynucleotide aesthetic treatments remains developing, and product type, concentration, injection technique and treatment protocol vary considerably between studies.
Depending on individual suitability and response, polynucleotide treatment may be considered for:
Polynucleotides cannot stop ageing or guarantee complete correction of any concern.
Depending on the approved product, practitioner competence and individual suitability, treatment areas may include:
Treatment may be considered for:
Polynucleotides may be used to support skin quality on the backs of the hands where clinically appropriate.
Not every formulation is suitable for every area.
Polynucleotides may be selected for delicate under-eye skin where the goal is to support skin quality rather than create significant volume.
The treatment may be considered for:
It may not correct:
The under-eye area requires advanced anatomical knowledge and careful assessment.
Polynucleotides and dermal fillers are injectable treatments but are generally selected for different purposes.
Polynucleotide treatment primarily focuses on:
It is not normally chosen to create significant facial volume.
Dermal fillers are commonly used to:
A consultation will help determine whether polynucleotides, dermal fillers or another approach is more suitable.
The terms may sometimes be used loosely in marketing, but the products and treatment objectives are not necessarily identical.
Some products or protocols may overlap in their intended cosmetic goals.
We’ll explain exactly which product we use, and why, at your consultation.
Polynucleotides and exosome-based treatments are different product categories.
Polynucleotide products contain purified chains of nucleotides and are commonly injected into selected skin areas.
Exosome formulations contain extracellular vesicles or related signalling components and may be used alongside procedures such as microneedling, depending on the product and protocol. Neither is better for everyone — we'll recommend the right option for your skin.
Your practitioner will ask:
You will be asked about:
The practitioner will review:
Your practitioner may discuss:
The plan should explain:
The skin will be examined and cleansed carefully.
Clinical photographs may be taken with consent.
A topical numbing product may be used where appropriate and legally suitable.
Some products may also contain a local anaesthetic, depending on the formulation.
Small amounts of product are placed into the selected skin area using a fine needle or cannula, depending on:
The practitioner will assess the area for:
Personalised aftercare and emergency-contact guidance will be provided.
Depending on the product and individual response, polynucleotides may help:
Results are not guaranteed.
Current systematic reviews describe the treatment as promising but also note limitations in the quality and consistency of the available evidence.
Polynucleotide treatment may be suitable for adults who:
There’s no set age for polynucleotides. We base suitability on your skin, your goals and your medical history.
Skin condition, goals and medical suitability are more relevant than age alone.
Treatment may need to be postponed or avoided if a client:
This list is not exhaustive.
Some polynucleotide products may be derived from purified fish DNA sources.
The exact source differs by product.
Every product we use is fully traceable, and we record the batch used in your treatment.
Clients must disclose relevant fish, salmon or other product-source allergies where applicable.
A course of approximately two to three sessions may commonly be recommended.
The exact plan depends on:
Appointments may be spaced approximately three to four weeks apart.
We’ll only suggest maintenance sessions if they will genuinely benefit your skin.
Some clients may begin to notice changes in hydration, smoothness or radiance within approximately two to four weeks.
Further changes may develop gradually after completing the recommended course.
The timing and extent of improvement vary.
Results may be affected by:
Many clients notice gradual changes within a few weeks, but everyone’s skin responds at its own pace.
Maintenance sessions may be recommended where clinically appropriate.
How long results last varies from person to person. We’ll review your skin and advise if and when a top-up would help.
Polynucleotide injections usually involve limited recovery, but visible temporary reactions are common.
These may include:
Under-eye swelling may be more noticeable and can sometimes last longer than expected.
Most temporary effects settle gradually, but recovery differs between clients.
Clients should allow sufficient recovery time before an important event.
As with any injectable procedure, polynucleotide treatment carries potential risks.
These may include:
Published studies often report temporary local effects such as pain, redness, swelling or bruising, but the available research is not large enough to rule out every uncommon complication.
You’ll receive aftercare written for your product and treatment area.
Following treatment, clients may be advised to:
You’ll receive aftercare written for your product and treatment area.
Clients may commonly be advised to avoid make-up for approximately 12–24 hours or until the skin is calm and intact.
Applying make-up too early may:
The exact recommendation should follow practitioner and product guidance.
Strenuous exercise can increase heat, blood flow, sweating and swelling.
Clients may be advised to avoid intense exercise for approximately 24 hours or longer where swelling remains visible.
Gentle daily activity may usually continue unless advised otherwise.
Certain polynucleotide products may be selected for the under-eye area.
Under-eye treatment commonly causes temporary swelling or small raised bumps.
The area requires careful anatomical assessment and advanced injection skills.
Dark circles have many possible causes, including:
Polynucleotide treatment may support the quality of delicate under-eye skin but cannot guarantee removal of dark circles.
The likely cause should be assessed before treatment.
Polynucleotides may sometimes be included within a wider treatment plan alongside:
Safe spacing depends on:
Treatments should not necessarily be delivered at the same appointment.
Transform Beauty offers a professional, consultation-led approach in the heart of Horsham.
Our practitioners consider:
We do not believe in treating every client in the same way or recommending injectables where the likely benefit is limited.
Our aim is to provide clear advice, realistic expectations and subtle skin-quality support.
Polynucleotide treatments may be incorporated into a wider approach to skin health, hydration, beauty, confidence and proactive ageing.
Transform Elite is our premium beauty, skin and longevity membership experience, created to help clients become more consistent and informed about their self-care.
Live Younger. Live Elite.
Polynucleotides are chains made from nucleotide units.
In aesthetics, highly purified polynucleotide formulations are injected into selected skin areas to support hydration, texture, elasticity and overall skin quality.
Polynucleotide products are injected into selected skin layers.
They are intended to support the local skin environment and may help improve hydration, texture, elasticity and overall skin appearance.
Results vary, and the evidence base is still developing.
Some products use polynucleotides derived from purified fish DNA sources, which may include salmon or trout.
The exact source depends on the product.
Your practitioner should explain the formulation and relevant allergy information before treatment.
They may help improve the appearance of:
Results vary.
Certain products may be suitable for the under-eye area.
Treatment may support hydration, texture and fine-line appearance but may not correct large eye bags, deep hollows or every cause of dark circles.
Most clients experience mild to moderate discomfort.
The sensation may include pinching, pressure, stinging or tenderness.
Comfort measures may be used where appropriate.
A course of approximately two to three treatments may be recommended.
The exact number and spacing depend on the product, treatment area, skin condition and individual response.
Some clients may notice gradual improvements within approximately two to four weeks.
Further changes may develop after completing the recommended course.
No particular timeframe or result can be guaranteed.
Result duration varies according to the product, treatment course, skin condition, lifestyle and individual response.
Maintenance may be recommended where appropriate.
Temporary redness, swelling, bruising, tenderness and visible injection points may occur.
Under-eye swelling can be particularly noticeable.
These effects commonly settle over several days, although individual recovery varies.
No.
Treatment may not be suitable for clients with active infection, certain allergies, relevant medical conditions, pregnancy, breastfeeding or other contraindications.
A full consultation is required.
Possible effects include redness, swelling, tenderness, bruising, itching, small lumps, infection, inflammation, allergic reaction and an unsatisfactory cosmetic result.
Product-specific risks will be explained during consultation.
Transform Beauty provides consultation-led polynucleotide treatments at 42 Carfax, Horsham, West Sussex RH12 1EQ.